Feasibility of Fluorescence Imaging with Bevacizumab-800CW During Bronchoscopy

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

June 1, 2026

Study Completion Date

December 1, 2026

Conditions
Lung NeoplasmsPulmonary NeoplasmsLymph Node Involvement
Interventions
DRUG

injection with 15 mg bevacizumab-800CW before bronchoscopy

Patients will receive an intravenous administration of 15 mg bevacizumab-800CW before the bronchoscopy procedure. The bronchoscopy will start with high-definition white light bronchoscopy, followed by fluorescence molecular bronchoscoy to observe the fluorescence signal and MDSFR-SFF spectroscopy to quantify the fluores-cence signal in vivo.

DRUG

injection with 25 mg bevacizumab-800CW before bronchoscopy

Patients will receive an intravenous administration of 15 mg bevacizumab-800CW before the bronchoscopy procedure. The bronchoscopy will start with high-definition white light bronchoscopy, followed by fluorescence molecular bronchoscoy to observe the fluorescence signal and MDSFR-SFF spectroscopy to quantify the fluores-cence signal in vivo.

All Listed Sponsors
lead

University Medical Center Groningen

OTHER