Vorasidenib Maintenance for IDH Mutant Astrocytoma

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

468

Participants

Timeline

Start Date

December 5, 2025

Primary Completion Date

April 13, 2035

Study Completion Date

May 31, 2037

Conditions
IDH-mutant Grade 2 or 3 Astrocytoma
Interventions
DRUG

Vorasidenib

Vorasidinib will be administered orally once daily at a dose of 40 mg in continuous 28-day cycles

DRUG

Vorasidenib Placebo

Matched oral vorasidenib placebo will be administered once daily in continuous 28-day cycles

Trial Locations (33)

Unknown

Medical University of Innsbruck, Innsbruck

Kepler University Hospital - Neuromed campus, Linz

Medical University of Vienna, Vienna

Universitair Ziekenhuis Brussel, Brussels

Ghent University Hospital, Ghent

U.Z. Leuven - Campus Gasthuisberg, Leuven

Masaryk Memorial Cancer Institute, Brno

Universitary hospital Bordeaux France, Bordeaux

CHU Lyon - Hopital neurologique Pierre Wertheimer, Lyon

Marseille APHM, Marseille

Assistance Publique Hopitaux de Paris APHP - Sorbonne, Paris

Oncopole Claudius Regaud, IUCT-Oncopole, Toulouse

Universitaskliniken Bonn, Bonn

University Hospital Frankfurt -Senckenberg Institute of Neurooncology, Frankfurt

NNeurology department heidelberg, Heidelberg

Mannheim University Hospital, Mannheim

Universitaetsklinikum Regensburg, Regensburg

Bellaria Hospital, IRCCS Istituto delle Scienze Neurologiche - AUSL di Bologna, Bologna

Veneto Institute of Oncology, Padua

Sapienza University, Roma

AOU Citta della Salute e della Scienza di Torino, Torino

Amsterdam UMC location VUMC, Amsterdam

Academisch Ziekenhuis Maastricht, Maastricht

Erasmus MC, Rotterdam

Hospital de Sant Pau i La Santa Creu, Barcelona

Vall de Hebron Hospital, Barcelona

Hospital Universitario 12 de Octubre, Madrid

University Hospital Basel, Basel

University Hospital Zurich, Zurich

Queen Elizabeth Hospital Birmingham, Birmingham

The Christie NHS Foundation Trust, Manchester

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

Royal Marsden Hospital, Surrey Quays

All Listed Sponsors
collaborator

Canadian Cancer Trials Group

NETWORK

collaborator

Cooperative Trials Group for Neuro-Oncology (COGNO)

UNKNOWN

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK