Intermittent Fasting for Inflammation and Depression in Spinal Cord Injury

NANot yet recruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 30, 2026

Study Completion Date

April 30, 2027

Conditions
Spinal Cord InjuryDepression - Major Depressive Disorder
Interventions
BEHAVIORAL

Intermittent fasting

Participants will follow a 16:8 protocol whereby they will be asked to fast for 16 hours per day and allowed to eat ad-libitum for the remaining 8 hours. While (for feasibility purposes) it will be a requirement that the fasting period include time spent asleep, participants will be allowed some degree of flexibility in the start and end time of their fasting period. This will be performed in order to accommodate participant preferences (sleeping/eating/medication schedules) as best as possible and provide a sense of autonomy. During the non-fasting hours, participants will be permitted to eat ad libitum.

BEHAVIORAL

Behavioral Support Strategies

Evidence-based self regulatory health behaviour support techniques including education, ongoing tailored feedback and encouragement, self monitoring tools, and goal setting will be used to help participants adhere to the fasting protocol. These techniques will be implemented via weekly phone calls to allow for coaching (e.g. barrier identification, strategies/action planning to overcome barriers, goal setting) as well as a smartphone app. The smartphone application will provide information pertaining to intermittent fasting including lay summaries of clinical trials as well as infographics related to healthy eating for the ad-libitum eating periods. Tips for healthy eating on a budget and adhering to an intermittent fasting protocol will also be provided. The smartphone app will also feature intermittent fasting start and stop time reminders, hydration reminders, and the ability to set one's individualized fasting schedule and record actual daily fasting windows.

Trial Locations (1)

N6C 0A7

Parkwood Institute, St Joseph's Health Care London, London

All Listed Sponsors
lead

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

OTHER

NCT06807528 - Intermittent Fasting for Inflammation and Depression in Spinal Cord Injury | Biotech Hunter | Biotech Hunter