Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Challenge Compared to DENV and ZIKV-naïve Controls Against Infection With ZIKV-SJRP Challenge

PHASE1RecruitingINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

September 24, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Zika Virus
Interventions
BIOLOGICAL

TetraVax-DV-TV003 (TV003)

0.5 ml of TV003 delivered via subcutaneous injection. TV003 contains 10\^3.3 plaque forming units (PFU)/mL of rDEN1Δ30, 10\^3.3 PFU/mL of rDEN2/4Δ30(ME), 10\^3.3 PFU/mL of rDEN3Δ30/31- 7164 and 10\^3.3 PFU/mL of rDEN4Δ30

BIOLOGICAL

Plasmalyte

0.5 mL of PlasmaLyte delivered via subcutaneous injection

BIOLOGICAL

Challenge virus ZIKV-SJRP/2016-184

0.5 ml of ZIKV-SJRP/2016-184 delivered via subcutaneous injection. ZIKV-SJRP/2016-184 contains a dose of 10\^2 plaque-forming units (PFU).

Trial Locations (2)

21205

RECRUITING

Center for Immunization Research, Johns Hopkins School of Public Health, Baltimore

21224

RECRUITING

Center for Immunization Research, Baltimore

All Listed Sponsors
collaborator

Johns Hopkins Bloomberg School of Public Health

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH