26
Participants
Start Date
September 24, 2024
Primary Completion Date
September 30, 2025
Study Completion Date
September 30, 2025
TetraVax-DV-TV003 (TV003)
0.5 ml of TV003 delivered via subcutaneous injection. TV003 contains 10\^3.3 plaque forming units (PFU)/mL of rDEN1Δ30, 10\^3.3 PFU/mL of rDEN2/4Δ30(ME), 10\^3.3 PFU/mL of rDEN3Δ30/31- 7164 and 10\^3.3 PFU/mL of rDEN4Δ30
Plasmalyte
0.5 mL of PlasmaLyte delivered via subcutaneous injection
Challenge virus ZIKV-SJRP/2016-184
0.5 ml of ZIKV-SJRP/2016-184 delivered via subcutaneous injection. ZIKV-SJRP/2016-184 contains a dose of 10\^2 plaque-forming units (PFU).
RECRUITING
Center for Immunization Research, Johns Hopkins School of Public Health, Baltimore
RECRUITING
Center for Immunization Research, Baltimore
Johns Hopkins Bloomberg School of Public Health
OTHER
National Institute of Allergy and Infectious Diseases (NIAID)
NIH