NCT06802666View on ClinicalTrials.gov

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

October 16, 2024

Primary Completion Date

September 1, 2026

Study Completion Date

December 30, 2027

Conditions
Locally Advanced Rectal CancerNeoadjuvant Therapy
Interventions
RADIATION

short-course radiotherapy

Eligible subjects will receive short-course radiotherapy (SCRT). One week after the end of treatment, subjects continued to receive neoadjuvant chemotherapy combined with AK112 regimen for 6 cycles.

DRUG

Ivonescimab

AK112 20 mg/kg, intravenous infusion every 3 weeks (Q3W)

DRUG

capecitabine

1000mg/m2, bid, po, d1-14,q3w

DRUG

oxaliplatin

130mg/m2, ivgtt, d1,q3w

PROCEDURE

TME surgery

The surgery was performed 1 week after the end of neoadjuvant therapy.

Trial Locations (1)

Unknown

RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei

All Listed Sponsors
lead

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER