A Study Evaluating Neoadjuvant Chemoimmunotherapy With Immunosensitizing Radiation for Borderline Resectable Non-Small Cell Lung Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 22, 2025

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2030

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Nivolumab

This will be administered intravenously once every 3 weeks for up to 3 cycles (i.e. 9 weeks of total systemic therapy)

DRUG

Chemotherapy

Chemotherapy options include: carboplatin or cisplatin along with pemetrexed, paclitaxel or gemcitabine

RADIATION

SBRT

Three fractions of radiation delivered every other day, for three total days. The final dose of radiation will happen within 7 days of starting chemoimmunotherapy

PROCEDURE

Surgical Resection

Post treatment patient will be evaluated for surgical resection

Trial Locations (4)

21014

RECRUITING

Upper Chesapeake- Kaufman Cancer Center, Bel Air

21061

RECRUITING

Baltimore Washington Medical Center- Tate Cancer Center, Glen Burnie

21201

RECRUITING

Maryland Proton Treatment Center, Baltimore

RECRUITING

University of Maryland Greenebaum Cancer Center, Baltimore

All Listed Sponsors
lead

University of Maryland, Baltimore

OTHER