A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma

PHASE1RecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

January 31, 2025

Primary Completion Date

September 1, 2028

Study Completion Date

September 1, 2030

Conditions
Multiple MyelomaRelapse Multiple MyelomaRefractory Multiple Myeloma
Interventions
DRUG

Elranatamab

Bispecific T-cell engager antibody, 1.9 and 1.1 mL vials, via subcutaneous (under the skin) injection per protocol.

BIOLOGICAL

GM-CSF

Granulocyte-Macrophage Colony-Stimulating Factor, via subcutaneous (under the skin) injection per protocol.

BIOLOGICAL

DC/MM Fusion Vaccine

Dendritic Cell and tumor fusion vaccine, via subcutaneous (under the skin) injection per protocol.

Trial Locations (2)

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

NOT_YET_RECRUITING

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

David Avigan

OTHER