372
Participants
Start Date
March 20, 2025
Primary Completion Date
December 31, 2029
Study Completion Date
December 31, 2034
Patritumab deruxtecan
Administered via IV infusion as neoadjuvant treatment
Pembrolizumab
Administered via IV infusion as neoadjuvant treatment in Part 1 and via IV infusion as neoadjuvant and adjuvant treatment in Part 2
Paclitaxel
Administered via IV infusion as neoadjuvant treatment
Carboplatin
Administered via IV infusion as neoadjuvant treatment
Doxorubicin hydrochloride
Administered via IV infusion as neoadjuvant treatment in Arm C and an option for adjuvant treatment for participants with residual disease in Arms A and B in Part 2
Epirubicin hydrochloride
Administered via IV infusion as neoadjuvant treatment in Arm C and an option for adjuvant treatment for participants with residual disease in Arms A and B in Part 2
Cyclophosphamide
Administered via IV infusion as neoadjuvant treatment in Arm C and an option for adjuvant treatment for participants with residual disease in Arms A and B in Part 2
Capecitabine
Administered via oral tablets as an option for adjuvant treatment for participants with residual disease in Part 2
Olaparib
Administered via oral tablets as an option for adjuvant treatment for participants with germline BRCA mutations and residual disease in Part 2
RECRUITING
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2501), Taipei
RECRUITING
Taichung Veterans General Hospital ( Site 2502), Taichung
RECRUITING
National Cheng Kung University Hospital ( Site 2503), Tainan City
RECRUITING
Virginia Oncology Associates (VOA) ( Site 8001), Norfolk
RECRUITING
SCRI Oncology Partners ( Site 7000), Nashville
RECRUITING
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0003), Billings
RECRUITING
Orchard Healthcare Research Inc. ( Site 0006), Skokie
RECRUITING
Texas Oncology - DFW ( Site 8000), Dallas
RECRUITING
Houston Methodist Hospital ( Site 0022), Houston
RECRUITING
UCLA Hematology/Oncology - Parkside ( Site 0021), Santa Monica
RECRUITING
Northwest Cancer Specialists (Compass Oncology) ( Site 8003), Tigard
RECRUITING
Seoul National University Hospital ( Site 2400), Seoul
Collaborators (1)
Daiichi Sankyo
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY