Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL)

PHASE2RecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

October 1, 2028

Study Completion Date

April 30, 2030

Conditions
Marginal Zone LymphomaExtranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid TissueSplenic Marginal Zone LymphomaNodal Marginal Zone Lymphoma
Interventions
BIOLOGICAL

Epcoritamab

"Epcoritamab will be administered via subcutaneous (SC) injection using a step-up dosing schedule as follows:~* Cycle 1, Day 1: 0.16 mg~* Cycle 1, Day 8: 0.8 mg~* Cycle 1, Day 15: 3 mg~* Cycle 1, Day 22: 48 mg~* Cycles 2 to 3, Days 1, 8, 15 and 22: 48 mg~* Cycles 4 to 9, Days 1 and 15: 48 mg~* Cycles 10 to 12; Day 1: 48 mg"

Trial Locations (1)

33136

RECRUITING

University of Miami, Miami

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Genmab

INDUSTRY

collaborator

AbbVie

INDUSTRY

lead

Izidore Lossos, MD

OTHER