Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 1, 2025

Primary Completion Date

August 1, 2025

Study Completion Date

October 1, 2025

Conditions
DysbiosisGut -microbiotaMicrobiome AnalysisProbioticAntibiotic Prophylaxis
Interventions
DRUG

Placebo Capsule

Participants will receive an inert placebo capsule that matches the probiotic capsule in size, shape, and color. The placebo will be administered orally twice daily, starting 2 weeks before surgery and continuing for 2 weeks postoperatively.

DIETARY_SUPPLEMENT

Probiotic with Human Milk Oligosaccharides (HMO)

Participants will receive a dual-strain probiotic containing Human Milk Oligosaccharides (HMO) in capsule form. The probiotic will be administered orally twice daily, starting 2 weeks before surgery and continuing for 2 weeks postoperatively.

Trial Locations (6)

19107

Parvizi Surgical Innovation, Philadelphia

34098

Istanbul University Cerrahpasa, Istanbul

34457

Acıbadem International Joint Center, Istanbul

34752

Acibadem LABMED Laboratories, Istanbul

Acıbadem Mehmet Ali Aydınlar University, Istanbul

40002

Thonburi Trang Hastanesi, Thailand

All Listed Sponsors
collaborator

Acibadem University

OTHER

lead

Acibadem Maslak Hospital

OTHER

NCT06791993 - Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery | Biotech Hunter | Biotech Hunter