A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 31, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2028

Conditions
Paget Disease, ExtramammaryScrotum Disease
Interventions
DRUG

Disitamab Vedotin combined with Toripalimab

Disitamab Vedotin at a dosage of 2mg/kg and 3mg/kg of Toripalimab administered intravenously every 3 weeks (ivgtt q3w) is continued until disease progression, with the allowance for treatment discontinuation due to disease progression, death, intolerable toxicity, withdrawal of informed consent, initiation of new antineoplastic therapy, or other reasons specified in the protocol, with the earliest occurring event taking precedence. Alternatively, the study investigator may determine the need to discontinue treatment.

Trial Locations (1)

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

All Listed Sponsors
collaborator

Zhejiang Tumor Hospital

OTHER

collaborator

Fujian Provincial Hospital

OTHER

collaborator

Zhangzhou Affiliated Hospital of Fujian Medical University

OTHER

collaborator

Quanzhou First Hospital

OTHER

collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

lead

Fujian Medical University Union Hospital

OTHER