Peptide Vaccine for Fibrolamellar Hepatocellular Carcinoma Patients and Other Tumor Entities Carrying the Driver Fusion DNAJB1-PRKACA

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

November 30, 2028

Study Completion Date

November 30, 2028

Conditions
Fibrolamellar Hepatocellular Carcinoma (FLC)
Interventions
DRUG

Vaccination of Fusion-VAC-XS15

"FusionVAC-22 peptide will be administered subcutaneously (s.c.) with the TLR1/2 ligand XS15 (50 µg) emulsified in Montanide ISA 51 VG (1:1).~A total of two vaccinations are planned, 4 weeks apart from each other. If no sufficient T cell response is achieved at the end of treatment visit (28 days after last vaccination) a booster vaccination at day 56 (+7 days) after the second vaccination can be applied"

Trial Locations (2)

72076

University Hospital Tuebingen, Tübingen

Universitätsklinikum Tübingen, Kinderheilkunde I, Tübingen

All Listed Sponsors
lead

University Hospital Tuebingen

OTHER