192
Participants
Start Date
October 31, 2025
Primary Completion Date
October 31, 2027
Study Completion Date
October 31, 2027
magnesium sulfate
After initial therapy with the systemic CSs routinely used for acute asthma management at a given site, 3 treatments with inhaled salbutamol and ipratropium, eligible patients with PRAM ≥5 will, under the care of the research nurse, receive a 30-minute IV infusion of 75 mg/kg of Mg sulfate(maximum 2.0 g) \[experimental group\]
Normal Saline
After initial therapy with the systemic CSs routinely used for acute asthma management at a given site, 3 treatments with inhaled salbutamol and ipratropium, eligible patients with PRAM ≥5 will, under the care of the research nurse, receive a 30-minute IV infusion of 0.9% saline \[control group\].
Alberta Children's Hospital, Calgary
Stollery Children's Hospital, Edmonton
McMaster Children's Hospital, Hamilton
Children's Hospital of Eastern Ontario, Ottawa
The Hospital for Sick Children, Toronto
CHU-Sainte Justine Hospital, Montreal
Alberta Children's Hospital
OTHER
McMaster Children's Hospital
OTHER
Stollery Children's Hospital
OTHER
Children's Hospital of Eastern Ontario
OTHER
St. Justine's Hospital
OTHER
The Hospital for Sick Children
OTHER
Suzanne Schuh
OTHER