Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

228

Participants

Timeline

Start Date

July 30, 2025

Primary Completion Date

January 4, 2032

Study Completion Date

January 4, 2032

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

BIOLOGICAL

I-DXd

IV infusion

DRUG

Leucovorin

IV infusion

DRUG

Levoleucovorin

IV infusion

DRUG

5-Fluorouracil (5-FU)

IV Infusion

DRUG

Oxaliplatin

IV infusion

Trial Locations (21)

704

RECRUITING

National Cheng Kung University Hospital ( Site 1001), Tainan City

1211

RECRUITING

Hopitaux Universitaires de Geneve HUG. ( Site 1701), Geneva

7000

RECRUITING

Kantonsspital Graubuenden ( Site 1700), Chur

10400

RECRUITING

Ramathibodi Hospital ( Site 1103), Ratchathewi

11217

RECRUITING

Taipei Veterans General Hospital ( Site 1005), Taipei

35128

RECRUITING

Istituto Oncologico Veneto IRCCS ( Site 9202), Padua

59037

RECRUITING

CHU Lille - Institut Coeur Poumon ( Site 9100), Lille

100225

RECRUITING

National Taiwan University Hospital ( Site 1000), Taipei

130021

RECRUITING

Beijing Cancer Hospital ( Site 9500), Beijing

221000

RECRUITING

Xuzhou Central Hospital ( Site 9512), Xuzhou

230601

RECRUITING

The Second Affiliated Hospital of Anhui Medical University ( Site 9511), Hefei

330006

RECRUITING

The First Affiliated Hospital of Nanchang University ( Site 9505), Nanchang

361003

RECRUITING

The First Affiliated Hospital of Xiamen University ( Site 9503), Xiamen

450008

RECRUITING

Henan Cancer Hospital ( Site 9509), Zhengzhou

59062-000

RECRUITING

Liga Norte Riograndense Contra o Cancer ( Site 1301), Natal

656 53

RECRUITING

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 9000), Brno

464-8681

RECRUITING

Aichi Cancer Center ( Site 9702), Nagoya

277-8577

RECRUITING

National Cancer Center Hospital East ( Site 9701), Kashiwa

104-0045

RECRUITING

National Cancer Center Hospital ( Site 9700), Chūō

0379

RECRUITING

Oslo Universitetssykehus Radiumhospitalet ( Site 1501), Oslo

05505

RECRUITING

Asan Medical Center ( Site 9901), Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY