A Phase Ib/II Study of Adebrelimab in Combination with Capecitabine and Oxaliplatin in Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

August 3, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

December 31, 2026

Conditions
Gastric Cancer
Interventions
DRUG

Adebrelimab

"Phase I: Cohort 1: Adebrelimab 10 mg/kg Q3W plus capecitabine and oxaliplatin (XELOX regimen); 21-day treatment cycle; Cohort 2: Adebrelimab 1200 mg or 20 mg/kg Q3W plus capecitabine and oxaliplatin (XELOX regimen); 21-day treatment cycle.~Phase II: Adebrelimab (RP2D, Q3W) + (XELOX regimen), with a 3-week (21-day) treatment cycle.~XELOX regimen:Oxaliplatin 130 mg/m2 iv.gtt d1,Capecitabine 1,000 mg/m2 p.o.b.i.d.d1\~14."

Trial Locations (1)

518100

RECRUITING

Shenzhen Hospital, Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen

All Listed Sponsors
lead

Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center

OTHER