Reducing Dose and Irradiated Volume in Cervical Prophylactic Irradiation for Nasopharyngeal Cancer

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

474

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

April 1, 2027

Study Completion Date

April 1, 2030

Conditions
Nasopharyngeal Carcinoma
Interventions
RADIATION

IMRT with reduced-dose and reduced-volume cervical prophylactic irradiation

For N0 disease, only cover bilateral RPN and level II. For N1 disease, cover ipsilateral involved level plus subsequent level downword, and cover contralateral level RPN and level II. For N2 disease, cover ipsilateral involved level plus subsequent level downword. For N3 disease, cover ipsilateral involved level plus subsequent level downword, and ensuring a 2cm margin below GTVn if GTVn reach or near the sternoclavicular joint. Notably, for unilateral N3, the contralateral neck would only include RPN and level II. Prescribing dose for CTVn2 was 50Gy/33Fx.

All Listed Sponsors
lead

Fujian Cancer Hospital

OTHER_GOV