CPAP Randomized Controlled Trial

NANot yet recruitingINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

February 28, 2025

Primary Completion Date

September 30, 2027

Study Completion Date

January 31, 2028

Conditions
Obstructive Sleep Apnea (OSA)Mild Cognitive Impairment (MCI)Cognitive Decline Prevention in Pre-frail Older Adults
Interventions
COMBINATION_PRODUCT

CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health

Participants in Group 1 will receive CPAP therapy immediately upon enrollment alongside web-based sleep education through the Brain Health Pro (BHP) platform. The CPAP intervention includes a study-provided auto-titrating device, in-person mask fitting, and ongoing support from a study sleep technologist. Adherence will be monitored via remote data uploads. The BHP platform is a 45-week web-based formal educational program program designed to increase dementia literacy, foster engagement, and convey best available evidence for lifestyle changes that can mitigate dementia risk. This combined approach ensures simultaneous initiation of CPAP and educational reinforcement to optimize adherence and cognitive outcomes.

COMBINATION_PRODUCT

Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health

Participants in Group 2 will begin with 4 months of BHP web-based sleep education before adding CPAP therapy for the remaining 4 months. CPAP setup and support are identical to the Early CPAP group. Participants in Group 2 will experience procedure similar to current clinical practices.

Trial Locations (1)

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

All Listed Sponsors
collaborator

Baycrest

OTHER

collaborator

University Health Network, Toronto

OTHER

collaborator

Centre for Addiction and Mental Health

OTHER

lead

Sunnybrook Health Sciences Centre

OTHER

NCT06773416 - CPAP Randomized Controlled Trial | Biotech Hunter | Biotech Hunter