Safety and Efficacy of HCB101 in Combination With Multiple Agents in Patients With Advanced Solid Tumors

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8 mg/kg IV loading dose on Day 1 of cycle 1, then 6 mg/kg IV every 21 days;

840 mg IV on Day 1, cycled every 21 days;

130 mg/m2 IV on Day 1, cycled every 21 days

1000 mg/m2 PO BID on Days 1-14, Cycled every 21 days

8 mg/kg IV on Days 1 and 15, Cycled every 28 days

80 mg/m2 IV on Days 1, 8, and 15, Cycled every 28 days

5 mg/kg IV on Day 1, Repeat every 2 weeks; or 7.5 mg/kg IV on Day 1, Repeat every 3 weeks.

400 mg/m2 first infusion, followed by 250 mg/m2 IV weekly; or 500 mg/m2 IV over 2 hours on Day 1 every 2 weeks;

180 mg/m2 IV over 30-90 minutes on Day 1 every 2 weeks

400 mg/m2 IV on Day 1 every 2 weeks

400 mg/ m2 IV bolus on Day 1, followed by 1200 mg/m2/day x 2 days (total 2400 mg/m2 over 46-48 hours) IV continuous infusion Repeat every 2 weeks

240 mg/kg IV on Day 1 Cycled every 21 days

125 mg/m2 IV on day 1 and Day 8 Cycled every 21 days

200 mg IV day 1; given every 21 days

1000 mg/m2 IV days 1 and 8