BCMA/CD3 BiTE for RRAL or NDAL Amyloidosis With Insufficient Depth of Hematologic Response After Induction Therapy

NANot yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

August 1, 2026

Study Completion Date

August 1, 2028

Conditions
AL Amyloidosis
Interventions
DRUG

CM-336 BCMA/CD3 bispecific antibody

Patients received subcutaneous CM-336 80 mg once weekly in 28-d cycles after two step-up priming doses of 3 mg and 20 mg given on day 1 and day 4 of cycle 1. For patients achieve hematological PR or better after 2 cycles, and hematological VGPR or better after 4 cycles, the treatment regimen will change to 160mg once every 2 weeks (Q2W).

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Keymed Biosciences Co.Ltd

INDUSTRY

lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER

NCT06769555 - BCMA/CD3 BiTE for RRAL or NDAL Amyloidosis With Insufficient Depth of Hematologic Response After Induction Therapy | Biotech Hunter | Biotech Hunter