NCT06767358View on ClinicalTrials.gov

Ketamine Sedation in the ICU (KANINE) RCT

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

November 30, 2027

Study Completion Date

December 31, 2027

Conditions
Mechanical VentilationCritically Ill Intensive Care Unit Patients
Interventions
DRUG

ketamine hydrochloride

Continuous adjunctive ketamine infusion at a fixed dose of 0.50mg/kg/hour

OTHER

Normal saline placebo

Normal saline placebo infusion

Trial Locations (3)

L8N 4A6

St. Joseph's Healthcare Hamilton, Hamilton

L8V1C3

Hamilton Health Sciences, Hamilton

M5G1X5

Mount Sinai Hospital, Toronto

All Listed Sponsors
lead

McMaster University

OTHER