200
Participants
Start Date
March 31, 2025
Primary Completion Date
March 31, 2030
Study Completion Date
March 31, 2030
a second infusion of ZOL when crosslaps levels reach 300 pg/mL
a first infusion of ZOL 5 mg, 6 months after denosumab withdrawal (= study start) and a second infusion when crosslaps levels reach 300 pg/mL, no later than month-12
a rescue second infusion at month-12 (standard traitment)
a first infusion of ZOL 5 mg, 6 months after denosumab withdrawal (= study start), and potentially a rescue second infusion at month-12, in case unfavourable outcome (incident osteoporotic fractures) or high risk of unfavourable outcome
Amiens Hospital, Amiens
Bordeaux Hospital, Bordeaux
Cahors Hospital, Cahors
Dax Hospital, Dax
Le Mans Hospital, Le Mans
Lille Hospital, Lille
Limoges Hospital, Limoges
Marseille Hsopital, Marseille
Montpellier Hospital, Montpellier
Nice Hospital, Nice
Orléans Hospital, Orléans
Cochin Hospital, Paris
Lariboisiere Hospital, Paris
Poitiers Hospital, Poitiers
Rennes Hospital, Rennes
Saint Etienne Hospital, Saint-Etienne
Toulouse Hospital, Toulouse
University Hospital, Toulouse
OTHER