Crisugabalin for Radiotherapy-Related Neuropathic Pain

PHASE2RecruitingINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

May 7, 2025

Primary Completion Date

November 30, 2026

Study Completion Date

December 31, 2026

Conditions
Neuropathic Pain
Interventions
DRUG

Crisugabalin

"Days 1-14: Crisugabalin 40 mg/day, 20 mg twice daily, orally. Days 15-21: Increase dose to 80 mg/day, 40 mg twice daily. If not tolerated, maintain previous dose until the end of the treatment period.~Days 22-28: Increase dose to 120 mg/day, 60 mg twice daily. If not tolerated, maintain previous dose until the end of the treatment period."

DRUG

Pregabalin

"Days 1-7: Pregabalin 150 mg/day, 75 mg twice daily, orally. Days 8-14: Increase dose to 300 mg/day, 150 mg twice daily. Days 15-21: Increase dose to 450 mg/day, 225 mg twice daily. If not tolerated, maintain previous dose until the end of the treatment period.~Days 22-28: Increase dose to 600 mg/day, 300 mg twice daily. If not tolerated, maintain previous dose until the end of the treatment period."

Trial Locations (11)

41004

NOT_YET_RECRUITING

Changsha Central Hospital, Changsha

350014

NOT_YET_RECRUITING

Fujian Cancer Hospital, Fuzhou

410005

NOT_YET_RECRUITING

Hunan Provincial People's Hospital, Changsha

410007

NOT_YET_RECRUITING

Hunan Brain Hospital, Changsha

450003

NOT_YET_RECRUITING

Henan Cancer Hospital (Affiliated Cancer Hospital of ZhengzhouUniversity), Zhengzhou

510000

RECRUITING

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou

510060

NOT_YET_RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510095

NOT_YET_RECRUITING

Affillated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou

510120

NOT_YET_RECRUITING

The First Affiliated Hospital of Guangxi Medical University, Nanning

510370

NOT_YET_RECRUITING

The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou

528403

NOT_YET_RECRUITING

Zhongshan People's Hospital, Zhongshan

All Listed Sponsors
lead

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER