Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia

NACompletedINTERVENTIONAL
Enrollment

471

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

February 28, 2025

Study Completion Date

February 28, 2025

Conditions
Postoperative Cognitive ImpairmentOptic Nerve Sheath Edema
Interventions
DEVICE

PC Ventilation Modes

Following induction, Group I patients received mechanical ventilation using the PC mode. The anesthetic machine (MAQUET Flow-I, Italy) parameters were set as follows: The inspiratory pressure (Pins) was adjusted to maintain an end-tidal carbon dioxide concentration (ETCO2) of 4.0-5.0 kPa. Pure oxygen and air were utilized at 0.3 L/min each, with an oxygen content of 41%. The positive end-expiratory pressure (PEEP) was set at 10 cmH2O, with an inspiration-to-expiration ratio of 1:2, a respiratory rate of 16 breaths per minute, and an oxygen content of 41%.

DEVICE

VC Ventilation Modes

Following induction, Group II patients received mechanical ventilation using the VC mode. The anesthetic machine (MAQUET Flow-I, Italy) parameters were set as follows: The inspiratory pressure (Pins) was adjusted to maintain an end-tidal carbon dioxide concentration (ETCO2) of 4.0-5.0 kPa. Pure oxygen and air were utilized at 0.3 L/min each, with an oxygen content of 41%. The positive end-expiratory pressure (PEEP) was set at 10 cmH2O, with an inspiration-to-expiration ratio of 1:2, a respiratory rate of 16 breaths per minute, and an oxygen content of 41%.

DEVICE

PRVC Ventilation Modes

Following induction, Group III patients received mechanical ventilation using the PRVC mode. The anesthetic machine (MAQUET Flow-I, Italy) parameters were set as follows: The inspiratory pressure (Pins) was adjusted to maintain an end-tidal carbon dioxide concentration (ETCO2) of 4.0-5.0 kPa. Pure oxygen and air were utilized at 0.3 L/min each, with an oxygen content of 41%. The positive end-expiratory pressure (PEEP) was set at 10 cmH2O, with an inspiration-to-expiration ratio of 1:2, a respiratory rate of 16 breaths per minute, and an oxygen content of 41%.

Trial Locations (1)

014010

Inner Mongolia Baosteel Hospital, Baotou

All Listed Sponsors
collaborator

Inner Mongolia Baogang Hospital

OTHER

collaborator

The Affiliated Hospital of Inner Mongolia Medical University

OTHER

lead

Inner Mongolia University of Science and Technology

OTHER

NCT06764745 - Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia | Biotech Hunter | Biotech Hunter