532
Participants
Start Date
December 31, 2024
Primary Completion Date
December 31, 2025
Study Completion Date
July 1, 2026
intravenous tranexamic acid (TXA) infusion
Intravenous tranexamic acid will be administered as an initial dose of 1 g (10mL: 1g, diluted in 90 mL normal saline) over 10 minutes, followed by a maintenance dose of 1 g over 8 hours (10mL: 1g, diluted in 240 mL normal saline). Intensive blood pressure lowering will be maintained throughout the treatment period until 24 hours after onset.
Placebo
An intravenous placebo (10mL NS, diluted in 90mL NS) matching the specification and appearance of TXA will be administered as an initial bolus over 10 minutes, followed by a continuous infusion of placebo (10mL NS, diluted in 240mL NS) over 8 hours, with intensive blood pressure lowering maintained throughout the treatment period and continued until 24 hours after symptoms onset.
Xuanwu Hospital, Capital Medical University, Beijing
Xuanwu Hospital, Capital Medical University, Beijing
Beijing Municipal Health Commission
OTHER_GOV
Capital Medical University
OTHER
Suzhou First People's Hospital
UNKNOWN
Linyi People's Hospital
OTHER
Peking University Care Luzhong Hospital
OTHER
Wuzhou Red Cross Hospital
OTHER
Yantai Penglai Traditional Chinese Medicine Hospital
UNKNOWN
The First Affiliated Hospital of Hebei North University
OTHER
Jiaozuo Tumor Hospital
UNKNOWN
Hunan Provincial People's Hospital
OTHER
The People's Hospital of Liaoning Province
OTHER
The First People's Hospital of Qujing, Yunnan Province
UNKNOWN
Huizhou Third People's Hospital, Guangzhou Medical University
OTHER
Nanyang Nanshi Hospital, Henan University
UNKNOWN
Xing'anmeng People's Hospital
UNKNOWN
Beijing Aerospace Center Hospital
UNKNOWN
Xuanwu Hospital, Beijing
OTHER