Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

December 30, 2024

Primary Completion Date

December 30, 2028

Study Completion Date

December 30, 2030

Conditions
Peripheral T-cell Lymphoma
Interventions
DRUG

chidamide and golidocitinib

Enrolled patients will receive combination therapy with golidocitinib (150 mg QD or 150 mg QOD) and chidamide (20 mg BIW or 25 mg BIW); If the MTD is determined at Dose Level 1 (chidamide 20 mg BIW / golidocitinib 150 mg QD), Dose Level 0 (chidamide 20 mg BIW / golidocitinib 150 mg QOD) will be further investigated. If the MTD is not established after escalating to Dose Level 2 (chidamide 25 mg BIW / golidocitinib 150 mg QD), the recommended Phase 2 dose (RP2D) will be determined through investigator consensus.

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER

NCT06757387 - Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma | Biotech Hunter | Biotech Hunter