BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

February 4, 2025

Primary Completion Date

July 30, 2027

Study Completion Date

July 30, 2027

Conditions
Hormone-receptor-positive Breast CancerHER2-negative Breast CancerMetastatic Breast Cancer
Interventions
DRUG

BGB-21447

Administered orally.

DRUG

Fulvestrant

Administered via intramuscular injection.

DRUG

BGB-43395

Administered orally.

Trial Locations (16)

201321

RECRUITING

Fudan University Shanghai Cancer Centerpudong, Shanghai

300060

RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310016

RECRUITING

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

330006

RECRUITING

The First Affiliated Hospital of Nanchang University Branch Donghu, Nanchang

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510245

RECRUITING

Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South), Guangzhou

92663-4162

RECRUITING

Hoag Memorial Presbyterian, Newport Beach

52242-1009

RECRUITING

University of Iowa Hospitals and Clinics, Iowa City

77030-3907

RECRUITING

Md Anderson Cancer Center, Houston

98109-4433

NOT_YET_RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

NSW 2010

RECRUITING

Saint Vincents Hospital Sydney, Darlinghurst

NSW 2298

RECRUITING

Calvary Mater Newcastle, Waratah

QLD 4575

RECRUITING

Sunshine Coast University Private Hospital, Birtinya

VIC 3000

RECRUITING

Peter Maccallum Cancer Centre, Melbourne

VIC 3021

RECRUITING

Western Health Sunshine Hospital, St Albans

WA 6009

RECRUITING

Linear Clinical Research, Nedlands

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT06756932 - BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer | Biotech Hunter | Biotech Hunter