Comparing the Efficacy of Sintilimab Plus Nab-POF Regimen, Sintilimab Plus XELOX Chemotherapy, and Lenvatinib, Sintilimab Plus XELOX Chemotherapy in the Treatment of HER2-negative, Metastatic Gastric Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

141

Participants

Timeline

Start Date

December 25, 2024

Primary Completion Date

July 25, 2027

Study Completion Date

December 25, 2027

Conditions
Gastric (Stomach) Cancer
Interventions
DRUG

Sintilimab, oxalipaltin, 5FU,Nab-paclitaxel,lenvatinib

Patients were randomized in a 1:1:1 ratio to three treatment groups: control group A: pembrolizumab combined with XELOX regimen, the regimen was repeated every 3 weeks, and tumor efficacy was evaluated every 2 treatment cycles. Group B: treatment regimen was pembrolizumab combined with Nab-POF regimen, the regimen was repeated every 2 weeks, and tumor efficacy was evaluated every 3 treatment cycles. Group C: treatment regimen was pembrolizumab combined with XELOX regimen and lenvatinib, the regimen was repeated every 3 weeks, and tumor efficacy was evaluated every 2 treatment cycles.

Trial Locations (2)

200032

Fudan University Cancer Hospital, Shanghai

Fudan University Shanghai Cancer Center, Shanghai

All Listed Sponsors
lead

Fudan University

OTHER