Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

NARecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

April 11, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
Obese PatientsTobacco UseVeteransFamily History of Esophageal CancerBarrett Esophagus
Interventions
DIAGNOSTIC_TEST

Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.

"Esocheck (EC)/Esoguard (EG): EC is a encapsulated balloon device available commercially from Lucid Diagnostics (New York, NY). EG assay uses bisulfite sequencing for detection of aberrant methylation in the vimentin and cyclin A1 genomic loci, respectively.~EGD (upper endoscopy): EGD will be performed by gastroenterologists practicing in the Louis Stokes Cleveland VA Medical Center Endoscopy laboratories on the same day when EC/EG is performed."

Trial Locations (1)

44106

RECRUITING

VA Northeast Ohio Healthcare System, Cleveland

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

Louis Stokes VA Medical Center

FED