UB-VV400 in Combination With Rapamycin in Relapsed or Refractory B-cell Malignancies

PHASE1RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

April 11, 2025

Primary Completion Date

May 21, 2028

Study Completion Date

July 31, 2030

Conditions
Large B-cell Lymphoma
Interventions
GENETIC

UB-VV400

UB-VV400 is a third-generation, self-inactivating (SIN), replication-incompetent, lentiviral vector (LVV) investigational drug product

DRUG

Rapamycin

In DF Stage 2, Rapamycin will be given in combination with UB-VV400. For subjects receiving rapamycin, rapamycin dosing will be once daily with a planned start date of Day 4 (approximately 72 hours after the administration of UB-VV400) and continuing for up to 60 days, as tolerated.

Trial Locations (2)

Unknown

RECRUITING

The First Affiliated Hospital of Nanjing Medical University, Nanjing

NOT_YET_RECRUITING

Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin

All Listed Sponsors
collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

lead

Nanjing IASO Biotechnology Co., Ltd.

INDUSTRY