SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

January 14, 2025

Primary Completion Date

January 31, 2028

Study Completion Date

October 31, 2031

Conditions
Melanoma, Cutaneous Malignant
Interventions
BIOLOGICAL

IMA203

one-time administration of IMA203, and adjunctive therapy with low dose interleukin (IL)-2 for up to 10 days, starting approximately 24 h after IMA203 infusion, optional bridging therapy

BIOLOGICAL

nivolumab plus relatlimab

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

BIOLOGICAL

lifileucel

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

BIOLOGICAL

nivolumab

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

BIOLOGICAL

pembrolizumab

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

BIOLOGICAL

ipilimumab

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

DRUG

Dacarbazine

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

DRUG

temozolomide

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

DRUG

paclitaxel

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

DRUG

paclitaxel plus carboplatin

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

DRUG

Albumin-Bound Paclitaxel

in accordance with current respective prescribing information (PI) and/or summary of product characteristics (SmPC)

Trial Locations (37)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

12203

RECRUITING

Charite Universitaetsmedizin Berlin KöR, Berlin

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

19104

RECRUITING

University of Pennsylvania, Abramson Cancer Center, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20246

RECRUITING

University Medical Center Hamburg-Eppendorf, Hamburg

21201

RECRUITING

University of MD Greenebaum Comprehensive Cancer Center, Baltimore

23219

RECRUITING

Virginia Commonwealth University, Richmond

27599

RECRUITING

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

33136

RECRUITING

University of Miami - Sylvester Comprehensive Cancer Cente, Miami

33612

RECRUITING

Moffitt Cancer Center, Tampa

37203

RECRUITING

SCRI Oncology Partners, Nashville

43210

RECRUITING

Ohio State University, Columbus

44195

RECRUITING

Cleveland Clinic, Taussig Cancer Institute, Cleveland

45147

RECRUITING

Universitaetsklinikum Essen AöR, Essen

50937

ACTIVE_NOT_RECRUITING

University Hospital Cologne AöR, Cologne

53127

ACTIVE_NOT_RECRUITING

Universitaetsklinikum Bonn AöR, Bonn

55131

RECRUITING

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz

57105

RECRUITING

Avera Cancer Institute, Sioux Falls

60590

RECRUITING

Goethe University Frankfurt, Frankfurt am Main

68198

RECRUITING

University of Nebraska Medical Center, Omaha

69120

RECRUITING

Universitaetsklinikum Heidelberg AöR, Heidelberg

75246

RECRUITING

Baylor University, Dallas

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

84112

RECRUITING

Huntsman Cancer Institute, University of Utah, Salt Lake City

85258

RECRUITING

Honor Health Research Institute, Scottsdale

90024

RECRUITING

UCLA Hematology/Oncology, Los Angeles

91010

RECRUITING

City of Hope National Medical Center, Duarte

91054

RECRUITING

Universitaetsklinikum Erlangen AöR, Erlangen

94305

RECRUITING

Stanford Cancer Center, Stanford

97213

RECRUITING

Providence Cancer Institute Franz Clinic, Portland

98109

ACTIVE_NOT_RECRUITING

Fred Hutchinson Cancer Center, Seattle

06510

RECRUITING

Yale Cancer Center, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

01307

RECRUITING

Technische Universitaet Dresden, Dresden

04103

ACTIVE_NOT_RECRUITING

Universitaet Leipzig, Leipzig

All Listed Sponsors
lead

Immatics US, Inc.

INDUSTRY