Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

June 1, 2027

Study Completion Date

December 31, 2027

Conditions
PTSDPost Traumatic Stress Disorder
Interventions
BEHAVIORAL

Traditional Exposure Therapy (ET) Treatment

Traditional exposure therapy (ET) includes the following components: (a) psychological education about trauma (sessions 1 and 2), (b) repeated in vivo exposure to trauma-related stimuli (in vivo exercises are assigned as homework during sessions 3 through 9), (c) repeated, prolonged, imaginal exposure to traumatic memories (imaginal exposure is implemented during sessions 3 - 9; patients listen to session audiotapes for homework between sessions), and (d) relapse prevention strategies and further treatment planning (session 10).

BEHAVIORAL

Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders

The Augmented Reality Exposure Therapy component includes the following: (a) 60-minute sessions dedicated to augmented reality exposure therapy (ARET; sessions 1-10), (b) repeated in vivo exposure to trauma-related stimuli (in vivo exercises are assigned as homework during sessions 3 through 9), and (c) relapse prevention strategies and further treatment planning (session 10). During ARET, the clinician guides participant, who is wearing augmented reality (AR) goggles, through preset scenarios during which characters mingle with each other (e.g., grocery store, social gathering), as well as custom scenarios where participant can interact with the character. Those who do not respond to treatment (i.e., responders defined as PCL score reduction of at least 12 points and final PCL score below 33) will then subsequently participate in 10 60-minute sessions of traditional exposure therapy (ET) identical to procedures described for the traditional ET arm.

Trial Locations (1)

29403

RECRUITING

Ralph H. Johnson VA Health Care System, Charleston

All Listed Sponsors
collaborator

Ralph H. Johnson VA Medical Center

FED

collaborator

United States Department of Defense

FED

lead

Wayne State University

OTHER

NCT06740487 - Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder | Biotech Hunter | Biotech Hunter