A Study Evaluating the Efficacy and Safety of De Trastuzumab (T-DXd) in Combination with Immunotherapy for the Neoadjuvant Treatment of HR-positive HER2 Low-expressing Chinese Patients with Early-stage Breast Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

January 1, 2028

Study Completion Date

January 1, 2029

Conditions
Breast Cancer, Estrogen Receptor-PositiveHER2 Low Breast Cancer
Interventions
DRUG

T-DXd combined with immune checkpoint inhibitor

Subjects who are eligible for the study and have signed informed consent will receive T-DXd in combination with an immune checkpoint inhibitor. The specific dosing regimen is as follows: T-DXd (5.4 mg/kg i.v. q3w) every 3 weeks for a total of 8 courses. Teraplizumab (240 mg/kg i.v. q3w), 1 course every 3 weeks for a total of 8 courses.

All Listed Sponsors
lead

Guangzhou Women and Children's Medical Center

OTHER