First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2)

PHASE2RecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

October 17, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
HER2-positive Gastric CancerMetastatic Gastric CancerUnresectable Gastric Carcinoma
Interventions
DRUG

Disitamab Vedotin

2.5 mg/kg IV every 3 weeks

DRUG

Sintilimab

200 mg IV every 3 weeks

DRUG

S-1

40-60 mg BID for 14 days, every 3 weeks

DRUG

Trastuzumab

First load dose is 8.0mg/kg , then 6.0 mg/kg IV every 3 weeks

DRUG

Oxaliplatin

130 mg/m2 Q3W

DRUG

Capecitabine

1000 mg/m² Q3W

DRUG

5-FU

800 mg/m²

DRUG

Cisplatin

80 mg/m²

Trial Locations (20)

250012

RECRUITING

Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan

RECRUITING

Shandong Provincial Third Hospital, Jinan

RECRUITING

Shandong Univerisity Qilu Hospital, Jinan

250063

RECRUITING

Qilu Hospital of Shandong University(Qingdao), Qingdao

277599

RECRUITING

Tengzhou Central People's Hospital, Tengzhou

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Unknown

NOT_YET_RECRUITING

Binzhou Medical University Hospital, Binzhou

RECRUITING

Shengli Oilfield Central Hospital, Dongying

RECRUITING

Jinan Third People's Hospital, Jinan

RECRUITING

Affiliated Hospital of Jining Medical College, Jining

RECRUITING

Liaocheng People's Hospital, Liaocheng

RECRUITING

Linyi Cancer Hospital, Linyi

NOT_YET_RECRUITING

The Affiliated Hospital of Qingdao University, Qingdao

NOT_YET_RECRUITING

Taian City Central Hospital, Taian

RECRUITING

The Second Affiliated Hospital of Shandong First Medical University, Taian

NOT_YET_RECRUITING

Weifang Hospital of Traditional Chinese Medicine, Weifang

RECRUITING

Yantai Yuhuangding Hospital, Yantai

RECRUITING

Yantaishan Hospital, Yantai

RECRUITING

Zibo Central Hospital, Zibo

RECRUITING

Zibo First People's Hospital, Zibo

All Listed Sponsors
lead

Qilu Hospital of Shandong University

OTHER