60
Participants
Start Date
November 30, 2025
Primary Completion Date
September 1, 2027
Study Completion Date
November 13, 2027
Sirolimus 0.5 Mg Oral Tablet
Sirolimus 0.5 mg oral tablets daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
Sirolimus 1Mg Oral Tablet
Sirolimus 1 mg oral tablets daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
Sirolimus 2 MG Oral Tablet
Sirolimus 2 mg oral tablets daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
Everolimus 0.5 MG Oral Tablet
Everolimus 0.5 mg oral tablets daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
Everolimus 1 MG Oral Tablet
Everolimus 1 mg oral tablets daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
Everolimus 2 MG Oral Tablet
Everolimus 2 mg oral tablets for daily for 2 weeks and complete PK/PD testing. After the first 2 weeks, dose increase, or dose reduction will be made to obtain a stable blood level of 5-7 ng/ml.
RECRUITING
UT Southwestern Medical Center, Dallas
University of Maryland, Baltimore
OTHER
National Institute on Aging (NIA)
NIH
University of Texas Southwestern Medical Center
OTHER