Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 31, 2024

Primary Completion Date

June 30, 2031

Study Completion Date

June 30, 2034

Conditions
Hepatocellular Carcinoma (HCC)Macrovascular InvasionLiver Transplant SurgeryDownstaging
Interventions
BIOLOGICAL

Atezolizumab & Bevacizumab

Atezolizumab \& Bevacizumab will be initiated as part of the study, as per standard treatment protocol. Administration of Atezolizumab and Bevacizumab will be performed according to SOC in approx. 21-days intervals. Clinical follow up during treatment will be done as per SOC in medical and surgical oncology clinics at UHN.

DRUG

Yttrium-90 (Y-90)

Storage, administration and treatment of Y90-RE will be done according to established treatment protocols and standard of care at UHN.

RADIATION

Stereotactic body radiotherapy (SBRT)

Dose and administration frequency of SBRT will be done as per current standards for treating HCC at UHN.

Trial Locations (2)

N6A 5A5

NOT_YET_RECRUITING

London Health Sciences Centre, London

M5G 2C4

RECRUITING

Toronto General Hospital, Toronto

All Listed Sponsors
lead

University Health Network, Toronto

OTHER