LEOPARD Prospective Validation Cohort 1

Not yet recruitingOBSERVATIONAL
Enrollment

630

Participants

Timeline

Start Date

January 31, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

October 31, 2027

Conditions
Decompensated Liver CirrhosisPrimary Biliary CholangitisPrimary Sclerosing CholangitisHepato-cellular Carcinoma
Interventions
OTHER

Standardized assessments, guided tumor biopsy and biobanking

"Standardized assessment of Scores~* Guided tumor biopsy in patients listed for hepatocellular carcinoma with active tumor at listing in centers not perfoming tumor biopsy on a routine basis~* Additional blood sampling for biobanking and subsequent analysis of innovative biomarkers and OMICs~* Urine sampling for biobanking and subsequent analysis of innovative biomarkers~* Ascite sampling for biobanking and subsequent analysis~* Tumor sampling for biobanking and subsequent analysis~* Centralized assay for routine biomarkers"

OTHER

Standardized assessments and biobanking

"* Standardized assessment of Scores~* Additional blood sampling for biobanking and subsequent analysis of innovative biomarkers and OMICs~* Urine sampling for biobanking and subsequent analysis of innovative biomarkers~* Ascite sampling for biobanking and subsequent analysis~* Tumor sampling for biobanking and subsequent analysis~* Centralized assay for routine biomarkers"

Trial Locations (5)

94010

Hospital Henri Mondor, Department of Hepatology, Créteil

Unknown

Department of Gastroenterology and Hepatology Universitair Ziekenhuis Gent, Ghent

Italian National Transplant Center, Roma

Center for Liver Tumors Leiden of the Leiden University Medical Center (LUMC), Leiden

Germany

"Universitätsklinikum Schleswig - Holstein , UKSH · Transplantation Medicine"

Sponsors
All Listed Sponsors
collaborator

University of Luxembourg

OTHER

collaborator

Hospital Universitario La Fe

OTHER

collaborator

ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK (ECRIN)

UNKNOWN

collaborator

Ophiomics - Precision Medicine

UNKNOWN

collaborator

EF CLIF

UNKNOWN

collaborator

INSERM 1149

UNKNOWN

collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

lead

Assistance Publique - Hôpitaux de Paris

OTHER

NCT06723275 - LEOPARD Prospective Validation Cohort 1 | Biotech Hunter | Biotech Hunter