328
Participants
Start Date
July 10, 2024
Primary Completion Date
July 30, 2025
Study Completion Date
August 30, 2025
Tecovirimat Oral Capsule [Tpoxx]
"Tecovirimat Oral Capsule 200 mg capsules~Number of capsules and frequency of dosage will be based on participant weight:~* ≥120 kg: three capsules three times a day (total daily tecovirimat dose: 1,800 mg)~* 40 to \<120 kg: three capsules twice a day (total daily tecovirimat dose: 1,200 mg)~* 25 to \<40 kg: two capsules twice a day (total daily tecovirimat dose: 800 mg)~* 13 to \<25 kg: one capsule twice a day (total daily tecovirimat dose: 400 mg)~* 6 to \<13 kg: ½ the contents of a capsule twice daily (total daily tecovirimat dose: 200 mg)~* 3 to \<6 kg: ¼ the contents of a capsule twice daily (total daily tecovirimat dose: 100 mg)"
Standard of Care (SOC)
Participants are provided SOC for mpox
L'Hôpital Général de Référence de Kole, Kole
L'Hôpital Général de Référence de Tunda, Tunda
Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo
OTHER
National Institute of Allergy and Infectious Diseases (NIAID)
NIH