HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

July 31, 2027

Study Completion Date

December 31, 2027

Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
DEVICE

Active HD-tDCS

10 sessions of anodal HD-tDCS stimulation (neurostimulator coupled with a 4x1 HD-tDCS multichannel adapter) with a defined electrical current intensity over the cortical representation zone of the left diaphragmatic motor cortex

DEVICE

Simulated HD-tDCS

10 sessions of sham anodal HD-tDCS stimulation (neurostimulator coupled with a 4x1 HD-tDCS multichannel adapter) over the cortical representation zone of the left diaphragmatic motor cortex. The device will provide a 30-second ramp and then maintain a minimal, non-effective continuous current

Trial Locations (4)

7500912

Universidad Autónoma de Chile, Santiago

8380453

Universidad do Chile, Santiago

72220-275

Universidade de Brasília - Campus Ceilândia, Brasília

59010-090

PneumoCardioVascular Lab - HUOL/UFRN, Natal

All Listed Sponsors
collaborator

Financiadora de Estudos e Projetos

OTHER

lead

Universidade Federal do Rio Grande do Norte

OTHER

NCT06719947 - HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial | Biotech Hunter | Biotech Hunter