47
Participants
Start Date
November 30, 2024
Primary Completion Date
November 29, 2028
Study Completion Date
November 29, 2028
Chemotherapy
Etoposide combined with cisplatin or carboplatin, administered every three weeks for a total of four cycles.
Immunotherapy
Toripalimab was administered concurrently with chemotherapy, every three weeks for four cycles.
Angio-immuno kinase inhibitor
Oral surufatinib 200 mg once daily (q.d.), given on days 1-14 of each chemotherapy cycle.
radiotherapy
Thoracic radiotherapy will begin no later than the start of the third chemotherapy cycle.
Prophylactic Cranial Irradiation
PCI is recommended after the completion of chemoradiotherapy.
Consolidation Therapy with Toripalimab and Surufatinib
Patients achieving complete response (CR), partial response (PR), or stable disease (SD) following chemoradiotherapy will receive consolidation therapy. Toripalimab: 240 mg intravenously on day 1, every three weeks. Surufatinib: 200 mg orally on days 1-14, every three weeks.
RECRUITING
Sun yat-sen University Cancer Center, Guangzhou
Sun Yat-sen University
OTHER