Concurrent Chemoradiotherapy Combined With Toripalimab and Surufatinib in the Treatment of Limited-Stage Small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

November 30, 2024

Primary Completion Date

November 29, 2028

Study Completion Date

November 29, 2028

Conditions
ToripalimabSurufatinibChemoradiotherapyLimited-stage Small Cell Lung Cancer (LS-SCLC)
Interventions
DRUG

Chemotherapy

Etoposide combined with cisplatin or carboplatin, administered every three weeks for a total of four cycles.

DRUG

Immunotherapy

Toripalimab was administered concurrently with chemotherapy, every three weeks for four cycles.

DRUG

Angio-immuno kinase inhibitor

Oral surufatinib 200 mg once daily (q.d.), given on days 1-14 of each chemotherapy cycle.

RADIATION

radiotherapy

Thoracic radiotherapy will begin no later than the start of the third chemotherapy cycle.

RADIATION

Prophylactic Cranial Irradiation

PCI is recommended after the completion of chemoradiotherapy.

DRUG

Consolidation Therapy with Toripalimab and Surufatinib

Patients achieving complete response (CR), partial response (PR), or stable disease (SD) following chemoradiotherapy will receive consolidation therapy. Toripalimab: 240 mg intravenously on day 1, every three weeks. Surufatinib: 200 mg orally on days 1-14, every three weeks.

Trial Locations (1)

510060

RECRUITING

Sun yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER