JAK1 Inhibitor Golidocitnib for the Treatment of Relapsed/refractory Indolent T/NK-cell Lymphomas

PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 15, 2024

Primary Completion Date

November 15, 2026

Study Completion Date

November 15, 2028

Conditions
Lymphoma, T-CellNK-LGL LeukemiaT-LGL LeukemiaCutaneous T Cell LymphomaCutaneous T Cell Lymphoma (CTCL)Large Granular Lymphocyte LeukemiaLarge Granular Lymphocytic LeukemiaIndolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal TractPrimary Cutaneous Acral CD8-Positive T-Cell LymphomaMycosis Fungoides
Interventions
DRUG

JAK1 Inhibitor

Golidocitnib 150mg QD orally, with a 28-day cycle. Efficacy will be evaluated once per cycle during the first year, and once every two cycles thereafter. Treatment will continue for up to 24 cycles, or until disease progression, lack of response within the first 6 cycles, or the occurrence of intolerable toxicity, whichever occurs first

Trial Locations (2)

300020

RECRUITING

Institute of Hematology & Blood Diseases Hospital, China, Tianjin

NOT_YET_RECRUITING

Institute of Hematology & Blood Diseases Hospital, Tianjin

All Listed Sponsors
collaborator

Tianjin First Central Hospital

OTHER

collaborator

The First Affiliated Hospital of Air Force Medicial University

OTHER

collaborator

The First Hospital of Jilin University

OTHER

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Second Xiangya Hospital of Central South University

OTHER

collaborator

Tongji Hospital

OTHER

lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER