Comparison of Pregnancy Outcomes in Women with Polycystic Ovarian Syndrome with and Without Glucophage

NANot yet recruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

February 2, 2025

Primary Completion Date

May 25, 2025

Study Completion Date

May 26, 2025

Conditions
Polycystic Ovarian Syndrome (PCOS)Pregnancy Outcomes
Interventions
PROCEDURE

Metformin (Glucophage)

In this intervention, participants will receive oral metformin (500 mg daily, gradually increasing to 1500 mg daily for non-obese participants and 2000 mg daily for obese participants) starting from the second week of pregnancy and continuing until delivery. Metformin will be administered in combination with a standard diet and exercise plan. The intervention aims to evaluate the impact of metformin on pregnancy outcomes in women with polycystic ovarian syndrome (PCOS), focusing on reducing complications such as early pregnancy loss, preterm delivery, gestational diabetes, and intrauterine growth restriction. Participants will be regularly monitored with follow-up visits, ultrasounds, and glucose tests to assess the effectiveness of the treatment.

PROCEDURE

Standard Care (Diet and Exercise Only)

In this intervention, participants will receive a standard diet and exercise plan designed to promote a healthy pregnancy. This intervention does not include any pharmacological treatment, such as metformin. The goal is to evaluate the pregnancy outcomes in women with polycystic ovarian syndrome (PCOS) managed with lifestyle modifications alone, without the added effect of medication. Participants will be monitored through regular follow-up visits, ultrasounds, and glucose tests to track pregnancy progress, including the occurrence of gestational diabetes, preterm delivery, early pregnancy loss, and fetal growth restriction.

All Listed Sponsors
lead

University of Health Sciences Lahore

OTHER

NCT06713967 - Comparison of Pregnancy Outcomes in Women with Polycystic Ovarian Syndrome with and Without Glucophage | Biotech Hunter | Biotech Hunter