NCT06712810 - Q702 for the Treatment of Patients With Hematologic Malignancies | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

August 27, 2025

Primary Completion Date

September 15, 2030

Study Completion Date

September 15, 2030

Conditions

Hematopoietic and Lymphatic System NeoplasmHistiocytic SarcomaMalignant HistiocytosisPeripheral T-Cell Lymphoma, Not Otherwise SpecifiedPrimary Cutaneous T-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Chronic Myelomonocytic LeukemiaRecurrent Follicular LymphomaRecurrent Langerhans Cell HistiocytosisRecurrent Lymphoplasmacytic LymphomaRecurrent Myelodysplastic SyndromeRecurrent MyelofibrosisRecurrent Small Lymphocytic LymphomaRecurrent Waldenstrom MacroglobulinemiaRefractory Chronic Lymphocytic LeukemiaRefractory Chronic Myelomonocytic LeukemiaRefractory Erdheim-Chester DiseaseRefractory Follicular LymphomaRefractory Langerhans Cell HistiocytosisRefractory Lymphoplasmacytic LymphomaRefractory Myelodysplastic SyndromeRefractory MyelofibrosisRefractory Small Lymphocytic LymphomaRefractory Waldenstrom MacroglobulinemiaRosai-Dorfman-Destombes DiseasePrimary Central Nervous System LymphomaRecurrent Blastic Plasmacytoid Dendritic Cell NeoplasmRecurrent Erdheim-Chester DiseaseRecurrent Fibroblastic Reticular Cell SarcomaRecurrent Histiocytic SarcomaRecurrent Interdigitating Dendritic Cell SarcomaRecurrent Rosai-Dorfman-Destombes DiseaseRefractory Blastic Plasmacytoid Dendritic Cell NeoplasmRefractory Fibroblastic Reticular Cell SarcomaRefractory Histiocytic SarcomaRefractory Interdigitating Dendritic Cell SarcomaRefractory Rosai-Dorfman-Destombes Disease

Interventions

DRUG

Axl/Mer/CSF1R Inhibitor Q702

Given PO

PROCEDURE

Biospecimen Collection

Undergo blood and urine sample collection

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow biopsy and aspiration

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy and aspiration

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET scan

OTHER

Survey Administration

Ancillary study

Trial Locations (2)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

85259

RECRUITING

Mayo Clinic in Arizona, Scottsdale