Phototoxicity of Frequently Prescribed Medicines

NACompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

September 22, 2022

Primary Completion Date

April 9, 2024

Study Completion Date

October 3, 2024

Conditions
Phototoxicity
Interventions
DRUG

Single oral dose of selected medicines, respectively

amiodarone (Amiodaron Arcana) 200mg, diclofenac (Diclobene) 100mg, hydrochlorothiazide (HCT G.L) 25mg, pantoprazole (Pantoloc) 40mg, voriconazole (Voriconazol Aristo®) 200mg

RADIATION

UVA and UVB radiation

The skin of the inner arm will be exposed to five fixed incremental doses of UVA and UVB. Each dose will be applied to a circular area on the inner forearm of 1 cm diameter for both UVA and UVB.

DRUG

Single oral dose of selected medicines, respectively

"acetylsalicylic acid (ASS Genericon) 500mg, doxycycline (Doxybene) 200mg, enalapril (Enalapril ratiopharm) 10mg, furosemide (Lasix) 40mg, verapamil (Verapabene) 80mg"

Trial Locations (1)

1090

Medical University of Vienna, Department of Clinical Pharmacology, Vienna

All Listed Sponsors
lead

Medical University of Vienna

OTHER