HDAC Inhibitor Combination with Chemoimmunotherapy in the Neoadjuvant Treatment of PMMR Locally Advanced Colon Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 15, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2027

Conditions
Colon Adenocarcinoma
Interventions
DRUG

Chidamide + Tislelizumab + chemotherapy (CapeOX )

Chidamide + Tislelizumab + chemotherapy (CapeOX regimen): 4 cycles of combination therapy (q3w; Day1 Oxaliplatin, 130mg/m2, iv.gtt; tislelizumab, 200mg/m2 iv.gtt; Day1,4,8,11Chidamide 20 mg BIW,PO; Day1-Day14, capecitabine 850-1000mg/m2, BID, PO) ;After completing the surgery, Post-operation 4 cycles of Capeox

DRUG

CapeOX

4 cycles (q3w; Day1 Oxaliplatin, 130mg/m2, iv.gtt; Day1-Day14, capecitabine, 850-1000mg/m2, BID, PO. ) Post-operation 4 cycles of Capeox

Trial Locations (1)

400000

RECRUITING

Daping Hospital, Third Military Medical University, Chongqing

All Listed Sponsors
collaborator

Southwest Hospital, China

OTHER

collaborator

Xinqiao Hospital of Chongqing

OTHER

collaborator

First Affiliated Hospital of Chongqing Medical University

OTHER

collaborator

The Second Affiliated Hospital of Chongqing Medical University

OTHER

collaborator

Chongqing Medical University

OTHER

collaborator

Chongqing University Cancer Hospital

OTHER

collaborator

Chongqing General Hospital

OTHER

collaborator

Chongqing Traditional Chinese Medicine Hospital

OTHER

collaborator

Chongqing Shapingba District People's Hospital

UNKNOWN

collaborator

Chongqing Seventh People's Hospital

UNKNOWN

collaborator

Chongqing Renji Hospital, University of Chinese Academy of Sciences

OTHER_GOV

collaborator

The 13th People's Hospital of Chongqing

UNKNOWN

lead

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

OTHER