NCT06709196View on ClinicalTrials.gov

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

PHASE4RecruitingINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

January 7, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
CystectomyBladder Cancer Requiring CystectomyPostoperative InfectionsAntibiotic ProphylaxisIleal Conduit
Interventions
DRUG

Pivmecillinam

Orally administered pivmecillinam 400mg

DRUG

Pivmecillinam

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Amoxicillin clavulanic acid

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Amoxicillin

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Cefuroxime

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Ciprofloxacin

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Linezolid

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Nitrofurantoin

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Trimethoprim

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Sulfamethoxazole trimethoprim

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

DRUG

Fluconazole

Orally administered targeted antimicrobial prophylaxis based on a urine culture.

Trial Locations (5)

2100

RECRUITING

Department of Urology, Rigshospitalet, Copenhagen

2730

NOT_YET_RECRUITING

Department of Urology, Herlev and Gentofte Hospital, Herlev

5000

NOT_YET_RECRUITING

Department of Urology, Odense University Hospital, Odense

8200

NOT_YET_RECRUITING

Department of Urology, Aarhus University Hospital, Aarhus

9100

NOT_YET_RECRUITING

Department of Urology, Aalborg University Hospital, Aalborg

All Listed Sponsors
lead

Rigshospitalet, Denmark

OTHER