NCT06708429View on ClinicalTrials.gov

Lynch Syndrome X-Talk of Enteral Mucosa With Immune System

RecruitingOBSERVATIONAL
Enrollment

300

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

June 1, 2033

Study Completion Date

June 1, 2034

Conditions
Lynch SyndromeLynch Syndrome ILynch Syndrome IILynch Syndrome I (Site-specific Colonic Cancer)HNPCCHNPCC Gene MutationHereditary Cancer SyndromeHereditary CancerMLH1 Gene MutationMLH1 Gene Deletion+DuplicationMLH1 Loss of ExpressionMLH1 Gene InactivationMSH2 Gene MutationMSH2 Gene Deletion+DuplicationMSH2 Loss of ExpressionMSH2 Gene InactivationMSH6 Gene MutationMSH6 Loss of ExpressionMSH6 Gene InactivationPMS2 Gene MutationPMS2 Gene InactivationPMS2 Loss of Expression
Interventions
DIAGNOSTIC_TEST

LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)

"A combination of blood-based, mucosal-based, and hair-based analyses that evaluate the presence and the expression of:~* a set of microRNAs (blood)~* antibodies anti-frame shift peptides (blood)~* mucosal-resident bacteria (healthy mucosa and cancer)~* environmental exposure to potential carcinogens (hair matrix)"

Trial Locations (5)

20132

RECRUITING

Gastronterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital, Milan

91016

RECRUITING

Beckman Research Institute at City of Hope, Monrovia

Unknown

RECRUITING

Dipartimento di Chirurgia Oncologica e Dipartimento di Oncologia Sperimentale Istituto Nazionale Tumori, Milan

RECRUITING

Dipartimento di controllo qualità e rischio chimico biologico, AOOR Villa Sofia Cervello, Palermo

RECRUITING

Chirurgia Generale, Azienda Ospedaliero Universitaria di Cagliari, Cagliari

All Listed Sponsors
lead

San Raffaele University

OTHER