The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)

NARecruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2025

Conditions
Kidney Failure, AcuteMyopathy; DrugsHeart ArrhythmiaSuccinylcholine SensitivityMuscle RelaxationGeneral Anesthetic Drug Adverse ReactionProjection
Interventions
DRUG

Propofol

"Induction of anaesthesia:~* Fentanyl 1-3ug/kg/m.c i.v.~* Ketamine 50mg i.v.~* Propofol 1.5-2mg/kg/m.c i.v.~* Rocuronium 5mg (b.w.\<60kg) 10mg (b.w.\>60kg) i.v. Precurarisation~* Chlorucinylcholine 1-1.5mg/kg/m.c i.v. -\> Intubation~Application (cycle of 5 pulses with 2000V biphasic alternating current) - during PFA:~\- In case of ventilatory distress pPeak \>30 cm H2O ad hoc Propofol 0.25-0.75mg/kg/m.c i.v.~Elimination of neuromuscular blockade:~\- To exclude residual relaxation after pre-curative: 1mg Atropine i.v. + 0.5mg Neostigmine i.v."

DRUG

Rocuronium

"Induction of anaesthesia:~* Fentanyl 1-3ug/kg/m.c i.v.~* Ketamine 50mg i.v.~* Propofol 1.5-2mg/kg/m.c i.v.~* Rocuronium 5mg (b.w.\<60kg) 10mg (b.w.\>60kg) i.v. Precurarisation~* Chlorucinylcholine 1-1.5mg/kg/m.c i.v. -\> Intubation~Application (cycle of 5 pulses with 2000V biphasic alternating current) - during PFA:~\- rocuronium 0.1-0.3mg/kg/m.c i.v. For TOF \<2~Abolition of neuromuscular blockade:~\- Atropine 1-1.5mg i.v. + 1-3mg Neostigmine i.v. Or Sugammadex 2-4mg/kg/m.c i.v."

Trial Locations (1)

50-981

RECRUITING

4th Military Clinical Hospital with Polyclinic, Wroclaw

All Listed Sponsors
lead

4th Military Clinical Hospital with Polyclinic, Poland

OTHER