A Multicenter, Randomized, Controlled,Open Label, Phase II Trial of Autologous Tumor Infiltrating Lymphocytes (GC101 TIL) in Subjects With Advanced Melanoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

December 20, 2024

Primary Completion Date

July 10, 2026

Study Completion Date

December 20, 2026

Conditions
Melanoma
Interventions
BIOLOGICAL

GC101 TIL

Patients with advanced melanoma (excluding uveal melanoma) who have failed to PD-1 antibodies (if BRAF mutation is present, BRAF and MEK inhibitors have failed; if NRAS mutation is present, tunlametinib have failed) and are ineligible for resection

DRUG

dacarbazine, temozolomide, paclitaxel ,platinum or cisplatin

monotherapy or combination of dacarbazine, temozolomide, paclitaxel, platinum or cisplatun, and the chemotherapy's dosage could refer to the drug label or the relevant treatment guideline, the final decision is up to investigator

Trial Locations (1)

Unknown

RECRUITING

Beijing Cancer Hospital, Beijing

All Listed Sponsors
lead

Shanghai Juncell Therapeutics

INDUSTRY