3,650
Participants
Start Date
May 19, 2025
Primary Completion Date
March 31, 2028
Study Completion Date
March 31, 2029
Nitric Oxide Gas
Patients will receive 80 parts per million (ppm) NO during CPB through the oxygenator. After weaning of CPB, test gases will be delivered via inspiration limb of ventilator at a dose range of 40-80 ppm until 6 hours after ICU admission or until extubation after surgery, whichever comes first.
Standard Care Arm
Patients in this group will receive standard care and 80 ppm nitrogen (N2, control group) are added to the gas mixture as control. In the circumstances when the N2 is not applicable, such as when the plasma-chemical NO synthesis device is employed for NO generatiaon and delivery, the device will be connected to the CPB and ventilator circuits, but the synthesis will remain inactive in the control group. Consequently, the circuit will be supplied with air devoid of NO.
NOT_YET_RECRUITING
Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk
RECRUITING
Xijing Hospital, Xi'an
NOT_YET_RECRUITING
Massachusetts General Hospital, Department of Anesthesia, Critical Care and Pain Medicine, Boston
Nikolay O. Kamenshchikov., M.D., Tomsk National Research Medical Center of the Russian Academy of Sciences
UNKNOWN
Lorenzo Berra., M.D., Massachusetts General Hospital
UNKNOWN
Jiange Han, Tianjin Chest Hospital, Tianjin, China
UNKNOWN
Qingping Wu, Wuhan Union Hospital, Wuhan, China
UNKNOWN
Evgeniy Grigoriev, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
UNKNOWN
Vladimir Boboshko, E. Meshalkin National Medical Research Center, Novosibirsk, Russian Federation
UNKNOWN
Andrei Bautin, The Almazov National Medical Research Centre, St. Petersburg, Russian Federation
UNKNOWN
Vladimir Pichugin, Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolev, Nizhny Novgorod, Russian Federation
UNKNOWN
Evgeniy Rosseykin, Federal Center of Cardiovascular Surgery, Khabarovsk, Russian Federation
UNKNOWN
Sheng Wang, Anzhen Hospital, Beijing, China
UNKNOWN
Xijing Hospital
OTHER