Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

July 10, 2025

Primary Completion Date

April 4, 2028

Study Completion Date

April 4, 2028

Conditions
Sickle Cell Disease Vaso-occlusive Crisis
Interventions
BIOLOGICAL

CSL889

CSL889 is a solution for infusion to be administered by the IV route.

DRUG

Placebo

Volume and regimen matched to CSL899 will be administered.

Trial Locations (17)

3000

UZ Leuven - Centrum voor Moleculaire en Vasculaire Biologie, Leuven

4000

CHR de la Citadelle, Liège

10029

Mount Sinai Medical Center, New York

10461

Jacobi Medical Center, The Bronx

10467

Albert Einstein College of Medicine, The Bronx

21201

University of Maryland, Baltimore

33908

Golisano Children's Hospital, Fort Myers

34093

Istanbul Universitesi - Cocuk Sagligi Enstitusu (Institute of Child Health), Istanbul

37134

AOUI Verona and University of Verona, Verona

43085

The Ohio State University, Columbus

45267

University of Cincinnati, Cincinnati

48202

Henry Ford Health System, Detroit

92868

University of California Irvine, Orange

33023-6703

The Foundation for Sickle Cell Disease, Hollywood

08950

Hospital Sant Joan de Déu, Barcelona

06230

Hacettepe Universitesi - Hacettepe Universitesi Hastaneleri, Ankara

01130

Özel Acibadem Adana Hastanesi, Seyhan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

CSL Behring

INDUSTRY

NCT06699849 - Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis | Biotech Hunter | Biotech Hunter